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KMID : 0881720000150020137
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Journal of Food Hygiene and Safety
2000 Volume.15 No. 2 p.137 ~ p.143
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Determination of Bioconcentration Factor on Phosphamidon and Profenofos by Flow-through Fish Test
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민경진:Min Kyung-Jin
차춘근:Cha Chun-Geun/서설:Seo Seol
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Abstract
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The present study was performed to investigate the bioconcentration of phosphamidon and profenofos. The BCFs(bioconcentration factors), depuration rate constants and LC_{50} for two pesticides in zebrafish(Brachydanio rerio) were measured by the flow-through system(OECD guideline 305). The results obtained are summarized as follows: The 24-hrs LC_{50}, 48-hrs LC_{50}, 72-hrs LC.n and 96-hrs LC_{50} were more than 100 mg/l for phosphamidon. The concentration of phosphamidon in zebrafish reached an equilibrium in 12 hrs at low and high concentrations(0.2 mg/l and 1 mg/1). The average BCF values of phosphamidon were less than 1 at low(0.96, n=7) and high concentrations (0.89, n=7) after 12∼168 hrs. Depuration rate constants of phosphamidon were 0.18 hr-1 and 0.21 hr-1, half-life of phosphamidon were 3.85 and 3.30 at low and high concentrations(0.2 mg/l and 1 mg/l), respectively, The concentrations of phosphamidon in zebrafish at low and high concentrations were rapidly decreased after 8(0.04 ㎍/g) and 12 hrs(0.07 ㎍/g). The 24-hrs LC_{50}, 48-hrs LC_{50}, 72-hrs LC_{50} and 96-hrs LC_{50} were 2.9, 2.6, 2.2 and 2.0 mg/1 for profenofos. The concentration of profenofos in zebrafish reached an equilibrium in 12 hrs at five-hundredth and one-hundredth concentration of 96-hrs LC_{50}(0.004 mgA and 0.02 mg/1). The average BCF values of profenofos were 141.9(n=7) and 111.3(n=7) at five-hundredth and one-hundredth concentration of 96-hrs LC_{50}(0.004 mg/l and 0.02 mg/1) after 12∼168 hrs. Depuration rate constants of profenofos were 0.09 hr^{-1} and 0.10 hr^{-1}, half-life of profenofos were 7.70 and 6.93 at five-hundredth and one-hundredth concentration of 96-hrs LC50(0.004 mg/l and 0.02 mg/1), respectively. The concentrations of profenofos in zebrafish at five-hundredth and one-hundredth concentration of 96-hrs LC_{50} decreased agter 8(0.18 ㎍/g) and 12 hrs (0.19 ㎍/g). The LC_{50} value in zebrafish showed that acute toxicity of profenofos was higher than that of phosphamidon. The BCF values of profenofos were 100 times higher than those of phosphamidon, and depuration rate of phosphamidon was two times faster than that of profenofos.
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KEYWORD
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Bioconcentration factor(BCF), Phosphamidon, Profenofos, Zebrafish(brachydanio rerio), Depuration rate constant
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